Product Name:

GDC-0449

Request
CAT#: A-1113    

Chemical Structure

GDC0449

Price of GDC-0449


Index Size Price
1 5mg $60
2 10mg $90
3 20mg $120
4 50mg $150
5 100mg Get quote, in stock
6 200mg Get quote, in stock
7 500mg Get quote, in stock
8 >=1000mg Get quote, in stock
9 We match the lowest price on market.
We offer a substantial discount on larger orders,
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We match the lowest price on market.

Biological Activity

An orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO
Technical Data

Formula:C19H14Cl2N2O3S
M.Wt: 421.3
CAS#:879085-55-9
Purity:>99%
Storage Conditions :Room temperature, or -20ºC for 2 year.
Reference