Product Name: GSK-1070916
 CAT#: A-1351

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 Synonym:GSK-1070916

GSK-1070916 Chemical Structure
GSK-1070916 chemical structure


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Biological Activity
GSK-1070916A is an ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types.
Technical Data

Mol. Formula: C30H33N7O
MW: 507.63
CAS#: 942918-07-2
Purity: >99%
GSK-1070916 MSDS GSK-1070916 CoA

Reference







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