Product Name:  GSK-2110183  Request GSK-2110183
CAT#: A-1503    

Chemical Structure

Price of GSK-2110183


IndexSizePrice
6200mgGet quote
7500mgGet quote
8>=1000mgGet quote
9We match the lowest price on market.
We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288
Biological Activity

GSK-2110183 is an orally bioavailable and selective Akt inhibitor which inhibits Akt 1, 2, 3, and Akt 1 E17K mutation at IC50 as 0.08 nM, 2 nM, 2.6 nM, and 0.2 nM, respectively.
GSK-2110183 is an orally bioavailable AKT inhibitor. GSK-2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Technical Data

Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference