Product Name: GSK-2879552

Request GSK-2879552

CAT#: A-1385


  Synonym:GSK-2879552,

GSK-2879552 Chemical Structure
GSK-2879552 chemical structure


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Biological Activity
GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.
Technical Data
Formula: C23H29ClN2O2
M.Wt: 400.94
Solubility: DMSO
CAS #:
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference




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