Product Name: I-BET151 (GSK1210151A)
 CAT#: A-1290

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 Synonym:I-BET151 ,GSK1210151A

I-BET151 (GSK1210151A) Chemical Structure
I-BET151 (GSK1210151A) chemical structure


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IUPAC/Chemical name: 7-(3,5-Dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-(2-pyridinyl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one, I-BET151

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Biological Activity
GSK1210151A (I-BET151) is an inhibitor of the BET (bromodomain and extra terminal domain protein) family of acetyl-lysine recognizing, chromatin ′adaptor′ proteins. GSK1210151A displaces BRD3 and BRD4, PAFc and SEC components from chromatin resulting in inhibition of transcription at key genes (BCL2, C-MYC and CDK6) involved in the initiation of mixed lineage leukemia (MLL). GSK1210151A (I-BET151) showed good efficacy in 2 MLL animal models.
Technical Data

Formula:C23H21N5O3
M.Wt:415.44
CAS#:1300031-49-5
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference







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