Product Name:

INCB-018424(Ruxolitinib)

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CAT#: A-1134    

Chemical Structure

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Biological Activity

INCB018424, an oral, selective JAK inhibitor.
Ruxolitinib (INCB018424) is a small-molecule ATP mimetic. It is an inhibitor of both JAK1 and JAK2, results in a dramatic decrease in levels of inflammatory cytokines, IL-6 and TNF-α . Ruxolitinib is clinically used for the treatment of myelofibrosis, a bone marrow disorder , and is being investigated for the treatment of certain cancers and autoimmune diseases, such as psoriasis.
Technical Data

Chemical Name: β
Formula:C17H18N6.H3PO4
M.Wt:404.36
CAS# 1092939-17-7
Optical purity: 100% by chiral HPLC
Chemical Purity: >98% by HPLC
Storage Conditions :Room temperature, or -20ºC for 2 year.
INCB-018424 MSDS INCB-018424 CoA
Reference