Product Name: INCB-24360

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CAT#: A-1521


  Synonym:INCB-24360,Epacadostat

INCB-24360 Chemical Structure INCB-24360 chemical structure


IUPAC/Chemical name: CHEMFIELD


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Biological Activity
Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).
Technical Data
M.Wt:      438.23
Formula:     C11H13BrFN7O4S
CAS#: 1204669-58-8
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.

Reference