Product Name: IPI-145
 CAT#: A-1274

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  Synonym:IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197

IPI-145 Chemical Structure
IPI-145 chemical structure


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IUPAC/Chemical name: (S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

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Biological Activity
IPI-145 is a potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma.
The PI3K-delta and PI3K-gamma isoforms are preferentially expressed in leukocytes (white blood cells), where they have distinct and non-overlapping roles in key cellular functions, including cell proliferation, cell differentiation, cell migration and immunity. Targeting PI3K-delta and PI3K-gamma may provide multiple opportunities to develop differentiated therapies for the treatment of blood cancers and inflammatory diseases.
Technical Data

Chemical Formula:C22H17ClN6O
W.Mt.:416.86
CAS#:1201438-56-3
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference



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