Product Name:  JNJ-26483327  Request JNJ-26483327
CAT#: A-1357    

Chemical Structure
LY2157299 chemical structure

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Biological Activity

JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).
Technical Data

Formula : C22H25BrN4O2
CAS# : 807640-87-5
M.Wt: 457.36
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

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