JNJ-31020028( Purity > 99% by HPLC)

Product Name: JNJ-31020028
 CAT#: A-1953

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 Synonym:JNJ-31020028; JNJ 31020028; JNJ31020028. ,

JNJ-31020028 Chemical Structure
JNJ-31020028chemical structure

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IUPAC/Chemical name:

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Biological Activity
JNJ-31020028 is a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. JNJ-31020028 bound with high affinity (pIC(50) = 8.07 +/- 0.05, human, and pIC(50) = 8.22 +/- 0.06, rat) and was >100-fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04 +/- 0.13) in functional assays. JNJ-31020028 occupied Y(2) receptor binding sites (approximately 90% at 10 mg/kg) after subcutaneous administration in rats. JNJ-31020028 increased norepinephrine release in the hypothalamus, consistent with the colocalization of norepinephrine and neuropeptide Y. In a variety of anxiety models, JNJ-31020028 was found to be ineffective, although it did block stress-induced elevations in plasma corticosterone, without altering basal levels, and normalized food intake in stressed animals without affecting basal food intake.
Technical Data

Purity: >99%
CAS#:1094873-14-9
Chemical Formula:C34H36FN5O2
Molecular Weight:565.6
JNJ-31020028 MSDSJNJ-31020028 CoA

IUPAC/Chemical name:N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
Canonical SMILES:O=C(NC1=CC=C(N2CCN(C(C3=CC=CC=C3)C(N(CC)CC)=O)CC2)C(F)=C1)C4=CC=CC=C4C5=CC=CN=C5
Reference





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