Product Name:  JNJ-42756493  Request JNJ-42756493
CAT#: A-1278    

Chemical Structure

JNJ-42756493 chemical structure

Price of JNJ-42756493


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Biological Activity

JNJ-42756493 is a pan-FGFR tyrosine kinase inhibitor.
An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.
Technical Data

Formula:C25H30N6O2
M.Wt:446.56
Solubility:DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
JNJ-42756493 MSDS JNJ-42756493 CoA
Reference