Product Name: KPT-330 (Selinexor)

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CAT#: A-6034


  Synonym:KPT-330, KPT330, Selinexor

KPT-330 Chemical Structure KPT-330 chemical structure


IUPAC/Chemical name: CHEMFIELD


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Biological Activity
Selinexor (KPT-330) is an orally available, small molecule inhibitor of XPO1, or CRM1 (chromosome region maintenance 1 protein), with potential antineoplastic activity. Selinexor modifies the essential CRM1-cargo binding residue cysteine-528, thereby irreversibly inactivating CRM1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (TSPs), including p53, p21, BRCA1/2, pRB, FOXO, and other growth regulatory proteins. As a result, this agent, via the approach of selective inhibition of nuclear export (SINE), restores endogenous tumor suppressing processes to selectively eliminate tumor cells while sparing normal cells. CRM1, the major export factor for proteins from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types.
Technical Data
M.Wt:      443.31
Formula:     C17H11F6N7O
CAS#: 1393477-72-9
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.

Reference