Product Name: KU-55933
 CAT#: A-1930

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KU-55933 Chemical Structure
KU-55933chemical structure

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IUPAC/Chemical name:

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Biological Activity
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1. KU-55933 (ATM Kinase Inhibitor) is a potent and specific inhibitor of ATM with IC50/Ki of 12.9 nM/2.2 nM, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
Technical Data

Purity: >99%
Chemical Formula:C21H17NO3S2
Molecular Weight:395.49
KU-55933 MSDSKU-55933 CoA

IUPAC/Chemical name:2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one
Canonical SMILES:C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

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