Product Name:  LBW-242  Request LBW-242
CAT#: A-1420    

Chemical Structure

LBW=242 chemical structure

Price of LBW-242


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Biological Activity

LBW242 is a Smac mimetic, and potent IAP inhibitor. LBW242 is effective against mutant FLT3 at doses that are physiologically achievable and well tolerated in vivo. LBW242 also enhances the inhibitory effects of PKC412, as well as standard chemotherapeutic agents such as doxorubicin and Ara-c, by acting in an additive-synergistic fashion against mutant FLT3-expressing cells in vitro. LBW242 also sensitizes ovarian cancer cells to the antitumor effects of TRAIL and anticancer drugs commonly used in clinic.
Technical Data

Chemical Formula: C27H42N4O2
Molecular Weight(M.Wt): 454.65
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference