Product Name: LGH-447
 CAT#: A-1512

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 Synonym:LGH-447,

LGH-447 Chemical Structure
LGH-447  chemical structure


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Biological Activity
An orally available pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor LGH447 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of the pro-apoptotic Bcl2 protein, and tumor cell apoptosis in cells that overexpress PIMs. PIM kinases, downstream effectors of many cytokine and growth factor signaling pathways, play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.
Technical Data

Purity: >99%
Solubility: DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
LGH-447 MSDS LGH-447 CoA

Reference







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