Product Name: LY-2835219
 CAT#: A-1407

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 Synonym:LY-2835219

LY-2835219 Chemical Structure
LY-2835219 chemical structure


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IUPAC/Chemical name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

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Biological Activity
LY2835219 is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Technical Data

Mol. Formula: C27H32F2N8
MW: 506.59339
CAS#: 1231929-97-7 (free base); 1231930-82-7 (mesylate salt)
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
LY-2835219 MSDS LY-2835219 CoA

Reference







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