Product Name: LY-2875358

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CAT#: A-1312


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Chemical Structure  chemical structure


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Biological Activity

anti-c-MET monoclonal antibody LY2875358
A humanized IgG4 monoclonal antibody directed against human hepatocyte growth factor receptor (HGFR or c-MET) with potential antineoplastic activity. Anti-c-MET monoclonal antibody LY2875358 binds to c-MET, thereby preventing the binding of HGF to its receptor c-Met and subsequent activation of the HGF/c-Met signaling pathway. This may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.

Technical Data
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.

Reference