Product Name: LY-3039478
LY-3039478 Chemical Structure
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LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I.
Chemical Formula: C22H23F3N4O4
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
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