Product Name: MGCD-516(Sitravatinib)Request MGCD-516(Sitravatinib)
MGCD-516(Sitravatinib) Chemical Structure
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Biological ActivitySitravatinib, also known as MGCD516 or MG516, is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. MGCD516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. MGCD516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth.
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