Product Name: MI-503
 CAT#: A-1399

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MI-503 Chemical Structure
MI-503  chemical structure

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Biological Activity
In a study just published in the scientific journal Cancer Cell, the University of Michigan researchers tested two compounds they developed, MI-463 and MI-503, in cell lines as well as in mice with mixed lineage leukemias. The Michigan researchers reported that the compounds blocked the menin-MLL interaction and effectively blocked the progression of the leukemia. The paper, titled “Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo” was made available on March 26, 2015 in the advanced online publication of Cancer Cell.
Technical Data

Chemical Formula:C28H27F3N8S
M.Wt.: 564.64
Purity: >98%
Solubility: DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
MI-503 MSDS MI-503 CoA

Cancer Cell
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
Borkin et al. develop highly potent and orally bioavailable small molecules that block the interaction between menin and MLL. These compounds inhibit the growth of model and patient-derived leukemia cells that express MLL-fusion proteins in vitro and prolong the survival of mice bearing MLL leukemia.
MI-503 chemical structure treatment efficacy

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