Product Name:

MK-2206

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CAT#: A-1206    

Chemical Structure

MK-2206 chemical structure

Price of MK-2206


The activities of in vitro and in vivo have been approved.

We offer a substantial discount on larger orders,
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Biological Activity

A oral potent allosteric Akt inhibitor (IC50=8nM,2nM,65nM for Akt1 Akt2 and Akt3 resp.)

Technical Data

M.Wt: 443.94
Formula: C25H21N5O.HCl
CAS Number: 1032350-13-2
Purity: >99%
Storage Conditions : Room temperature, or -20ºC for 2 year.

Reference
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
H Hirai, H Sootome, Y Nakatsuru, K Miyama¡­ - Molecular cancer..., 2010 - AACR

Targeting the cancer kinome through polypharmacology
ZA Knight, H Lin¡­ - Nature Reviews Cancer, 2010 - nature.com

The BATTLE Trial: A Bold Step toward Improving the Efficiency of Biomarker-Based Drug Development
EH Rubin, KM Anderson¡­ - Cancer Discovery, 2011 - AACR
... Similar to BATTLE, BATTLE-2 involves previously treated lung cancer patients and includes erlotinib and sorafenib treatment arms as well as 2 other investigational treatments: a combination of the AKT inhibitor MK-2206 with the MEK inhibitor AZD6244 and a combination of MK ...