Product Name: MK-4827 HCl (Niraparib)

Request MK-4827-HCL

CAT#: A-6032


  Synonym:MK-4827-HCL,

MK-4827-HCL Chemical Structure MK-4827-HCL chemical structure


IUPAC/Chemical name: CHEMFIELD


Price of MK-4827-HCL

We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com or Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
MK-4827 (Niraparib) is an inhibitor of PARP 1 and 2 with IC50 = 3.8 and 2.1 nM, respectively, currently in clinical trials. In a whole cell assay, it inhibited PARP activity with EC50 = 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Technical Data
M.Wt:      356.85
Formula:     C19H20N4O HCl
CAS#: 1038915-64-8
Purity: >99 % by HPLC, Chiral purity100%
Storage Conditions: Room temperature for short term or -20ºC for 2 years.

Reference