Product Name: NMS-1286937
 CAT#: A-1094

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 Synonym:NMS1286937

NMS-1286937 Chemical Structure
NMS-1286937 chemical structure


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IUPAC/Chemical name: 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

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Biological Activity
NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.
Technical Data

Mol. Formula: C24H27F3N8O3
MW: 532.21
CAS#: 1034616-18-6
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
NMS-1286937 MSDS NMS-1286937 CoA

Reference







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