NMS-873 Chemical StructureIUPAC/Chemical name: 3-(3-(cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)oxy)methyl)-4H-1,2,4-triazol-4-yl)pyridine.
Product Name: NMS-873Request NMS-873
Biological ActivityNMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor). NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.
Technical DataM.Wt: 520.67
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.