Product Name: NVP-LDE-225(Diphosphate salt)

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CAT#: A-1126


  Synonym:NVP-LDE225,Erismodegib

NVP-LDE-225 Chemical Structure NVP-LDE-225 chemical structure


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Biological Activity

Erismodegib (LDE225, NVP-LDE225) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.

Technical Data

Formula:    C26H26F3N3O3.2H3PO4
M.Wt:     681.5
CAS#:     1218778-77-8
Purity:     >99%
Solubility : DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference






Purchase(buy) LDE-225, an Hedgehog inhibitor, at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.