Product Name: OICR-9429
 CAT#: A-9063

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 Synonym:OICR-9429,

OICR-9429 Chemical Structure
OICR-9429  chemical structure


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IUPAC/Chemical name:

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Biological Activity
OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.1 For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.2 WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.1,3 OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = <1 µM).
Technical Data

Mol. Formula: C29H32F3N5O3
MW: 555.6
CAS#: 1801787-56-3
Purity: >99%
Solubility: DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
OICR-9429 MSDS OICR-9429 CoA

IUPAC/Chemical name: N-​(4-​(4-​methylpiperazin-​1-​yl)-​3'-​(morpholinomethyl)-​[1,​1'-​biphenyl]-​3-​yl)-​6-​oxo-​4-​(trifluoromethyl)-​1,​6-​dihydropyridine-​3-​carboxamide
SMILES code: O=C(C1=CNC(C=C1C(F)​(F)​F)​=O)​NC2=CC(C3=CC(CN4CCOCC4)​=CC=C3)​=CC=C2N5CCN(C)​CC5
Reference







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