Product Name: ONX-0912
 CAT#: A-1368

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 Synonym:ONX-0912,Oprozomibm

ONX-0912 Chemical Structure
ONX-0912 chemical structure


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IUPAC/Chemical name: N-((S)-3-methoxy-1-(((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide

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Biological Activity
Oprozomibm, also known as ONX 0912 and PR 047, is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated. Check for active clinical trials or closed clinical trials using this agent.
Technical Data

Mol. Formula: C25H32N4O7 S
MW: 532.61
CAS#: 935888-69-0
Purity: >99%
Chiral Purity: 100%
ONX-0912 MSDS ONX-0912 CoA

Reference







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