99% by HPLC, 100% by chiral HPLC - Purity whole section PUT image in userfiles/ and Storage condition at bottom, ADD pricing to price3.xml in PRODUCTS folder> PF-02341066 HCL(>99% by HPLC, 100% by chiral HPLC)|Supplier|Active Biochem

Product Name: PF-02341066 HCl (Crizotinib)

Request PF-02341066

CAT#: A-6033


  Synonym:PF-02341066,PF02341066,Crizotinib

PF-02341066 Chemical Structure PF-02341066 chemical structure


IUPAC/Chemical name:


Price of PF-02341066-HCL

R-Enantiomer, 100%

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Biological Activity
An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.
Technical Data
M.Wt:      486.8
Formula:     C21H22Cl2FN5O HCl
CAS#: 1415560-69-8
Solubility: DMSO
Purity: >99% by HPLC, 100% by chiral HPLC
Storage Conditions: Room temperature for short term or -20ºC for 2 years.

Reference