Product Name: PF-06463922

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CAT#: A-1329


  Synonym:PF-06463922,

PF-06463922 Chemical Structure
PF-06463922 chemical structure


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Biological Activity
An orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, ALK/ROS1 inhibitor PF-06463922 binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK- and ROS1-mediated signaling and eventually inhibits tumor cell growth in ALK- and ROS1-overexpressing tumor cells. In addition, PF-06463922 is able to cross the blood brain barrier. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells.
Technical Data
Chemical Formula:C21H49FN6O2
W.Mt.:406.42
CAS#:1454846-35-5
Purity: >99%
Choral Purity: 100%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference