Product Name:

PF-02341066(Crizotinib)

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CAT#: A-1031    

Chemical Structure

Price of PF-02341066(Crizotinib)

R-Enantiomer, 100%

The activities of in vitro and in vivo have been approved.

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Biological Activity

An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

Technical Data

Formula:    C21H22Cl2FN5O
M.Wt:     449.1
CAS#: 877399-52-5
Solubility: DMSO
Purity: >99%
Storage Conditions : Room temperature, or -20ºC for 2 year.

PF-2341066 MSDS PF-2341066 CoA
Reference