PLX-7904 Chemical Structure
PLX-7904 is a potent and selective paradox-breaker RAF inhibitor. PLX-7904 is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. Importantly, PLX-7904 inhibits ERK1/2 phosphorylation in mutant BRAF melanoma cells with acquired resistance to vemurafenib/PLX4720 that is mediated by a secondary mutation in NRAS. Consistent with ERK1/2 reactivation driving the re-acquisition of malignant properties, P PLX-7904 promoted apoptosis and inhibited entry into S phase and anchorage-independent growth in mutant N-RAS-mediated vemurafenib-resistant cells.
> 99% by HPLC
Room temperature for months, or -20ºC for 3 years.