Product Name: PT-2385
 CAT#: A-1510

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 Synonym:PT-2385,

PT-2385 Chemical Structure
PT-2385  chemical structure


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Biological Activity
An orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancers, promotes tumorigenesis.
Technical Data

Purity: >99%
Solubility: DMSO
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
PT-2385 MSDS PT-2385 CoA

Reference







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