RDEA-119 (BAY-869766)Request RDEA-119
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RDEA119 is an orally bioavailable potent (IC50 at low nM), selective MEK inhibitor with potential anti-cancer activity. RDEA119 specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.