Product Name:  RO-4929097  Request RO-4929097
CAT#: A-1263    

Chemical Structure

Price of RO-4929097


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Biological Activity

RO4929097 is a small molecule Gamma-Secretase inhibitor (IC?? = 4 nM). It binds to Gamma-Secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
Technical Data

Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference