Product Name:  RX-3117  Request RX-3117
CAT#: A-1364    

Chemical Structure
RX-3117 chemical structure

Price of RX-3117


We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288
Biological Activity

RX-3117, also known as TV-1360 and fluorocyclopentenylcytosine, is a potent DNA synthesis inhibitor. RX-3117 belongs to the class of cytotoxic antimetabolite nucleoside compounds. In vitro and in vivo studies have demonstrated successful preliminary efficacy and therapeutic potential. RX-3117 interferes with enzymes or metabolites responsible for the process of cell division, nucleic acid synthesis, arrests cells in G1 phase and induces apoptosis. RX-3117 also inhibits cdc2 kinase and DNMT-1 protein expression, which are further involved in cell division processes. RX-3117 is activated by uridine-cytidine kinase and is activated by a mechanism different from that of gemcitabine.
Technical Data

Formula : C10H12FN3O4
CAS# : 865838-26-2
M.Wt: 257.22
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference








Purchase(buy) inhibitor RX-3117 at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.