Product Name:

Regorafenib (BAY73-4506)

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CAT#: A-1112    

Chemical Structure

Regorafenib

Price of Regorafenib


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Biological Activity

Regorafenib (BAY73-4506) is an oral multikinase inhibitor, including B-Raf (IC50, 69 nM), c-KIT (IC 50, 17 nM), VEGFR2 (IC50, 40nM).
Technical Data

Chemical Formula: C21H15ClF4N4O3
CAS#: 755037-03-7
MW: 482.81
Storage Conditions :Room temperature, or -20ºC for 2 year.
Regorafenib MSDS Regorafenib CoA
Reference

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
SM Wilhelm, J Dumas, L Adnane...-...Journal of Cancer, 2011 - Wiley Online Library
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity-Wilhelm-2011- International Journal of Cancer-Wiley Online Library
Assessment of regorafenib activity with FDG-PET/CT in a multicenter phase II study in patients (pts) with advanced gastrointestinal stromal tumor (GIST) following...
AD Van Den Abbeele, Y Tanaka...- J Clin Oncol (..., 2011 - meeting.ascopubs.org
Background: FDG-PET/CT is a pharmacodynamic biomarker with imatinib (IM) and sunitinib (SU) in GIST and correlates with clinical activity. This study evaluated FDG-PET/CT in a phase II trial of pts following failure of IM and SU who received regorafenib, a novel oral ...