Product Name: S-63845

Request S-63845

CAT#: A-6044


  Synonym:S-63845,

S-63845 Chemical Structure S-63845 chemical structure


IUPAC/Chemical name: (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid


Price of S-63845

We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com or Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
S63845 is a potent and selective MCL1 inhibitor (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP) > 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway. In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers. Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines. These results point towards MCL1 as a target for the treatment of a wide range of tumours.
Technical Data
M.Wt:      829.26
Formula:     C39H37ClF4N6O6S
CAS#: 1799633-27-4
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.

Reference