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SB-939 is a novel histone deacetylase (HDAC) inhibitor with improved, pharmaceutical physicochemical, and pharmacokinetic properties. In vitro, SB-939 inhibits class I, II, and IV HDACs, with no effects on other zinc binding enzymes, and shows significant antiproliferative activity against a wide variety of tumor cell lines. SB-939 has very favorable pharmacokinetic properties after oral dosing in mice, with >4-fold increased bioavailability and 3.3-fold increased half-life over SAHA (Suberoylanilide Hydroxamic Acid).
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.