Product Name: SGI-110
SGI-110 Chemical Structure
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SGI-110 is a proprietary dinucleotide pro-drug of decitabine which is a second generation DNA methyltransferase inhibitor. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine.
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Purchase(buy) DNA methyltransferase inhibitor SGI-110 at Active Biochem
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