Product Name: SGI-110
 CAT#: A-1294

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 Synonym:SGI110

SGI-110 Chemical Structure
SGI-110 chemical structure


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Biological Activity
SGI-110 is a proprietary dinucleotide pro-drug of decitabine which is a second generation DNA methyltransferase inhibitor. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine.
Technical Data

Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.

Reference







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