Product Name: TAK-632
TAK-632 Chemical Structure
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TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. In addition, TAK-632 was shown preclinically to be a selective kinase inhibitor targeting pan-RAF kinase activity by testing against a panel of kinases. In both A375 (BRAFV600E) and HMVII (NRASQ61K) xenograft models in rats, TAK-632 demonstrated regressive antitumor efficacy by twice daily, 14-day repetitive administration without significant body weight loss.
Chemical Formula: C27H18F4N4O3S
Molecular Weight: 554.53
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Purchase(buy) DNA methyltransferase inhibitor TAK-632 at Active Biochem
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