Product Name: Birinapant (TL32711)

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CAT#: A-1901


  Synonym:TL-32711

TL-32711 Chemical Structure
TL-32711 chemical structure


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Biological Activity
TL-32711 is a SMAC (second mitochondrial-derived activator of caspases) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.
Technical Data
M.Wt:     806.91
Formula:     C42H56F2N8O6
CAS#:1260251-31-7
Optical purity :100% by chiral HPLC
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
TL-32711 MSDS TL-32711 CoA

Reference




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