Product Name:  VE-822  Request VE-822
CAT#: A-1613    

Chemical Structure
VE-822 chemical structure

Price of VE-822


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Biological Activity

VE-822 is an potent ATR inhibitor. VE-822 inhibited ATR in vitro and in vivo. VE-822 decreased maintenance of cell-cycle checkpoints, increased persistent DNA damage and decreased homologous recombination in irradiated cancer cells. VE-822 decreased survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine. VE-822 markedly prolonged growth delay of pancreatic cancer xenografts after XRT and gemcitabine-based chemoradiation without augmenting normal cell or tissue toxicity. These findings support ATR inhibition as a promising new approach to improve the therapeutic ration of radiochemotherapy for patients with PDAC.
Technical Data

Formula:C24H25N5O3S
M.Wt:463.55
CAS#:1232416-25-9
Solubility:Soluble in DMSO
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
Reference