Product Name: VS-4718/PND-1186
 CAT#: A-1356

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 Synonym:VS-4718/PND-1186,

VS-4718/PND-1186 Chemical Structure
VS-4718/PND-1186  chemical structure


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IUPAC/Chemical name:

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Biological Activity
An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival. The cytoplasmic tyrosine kinase FAK is a signal transducer for integrins and is constitutively activated in various tumor cell types; it is involved in tumor cell invasion, migration and proliferation and plays a key role in the development, function and survival of CSCs. Check for active clinical trials or closed clinical trials using this agent.
Technical Data

Mol. Formula: C25H26F3N5O3
MW: 501.5
CAS#: 1061353-68-1
Purity: >99%
Chiral Purity: 100%
VS-4718/PND-1186 MSDS VS-4718/PND-1186 CoA

Reference







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