VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK2 ( Ki < 2 nM) which exhibits potent cellular activity with IC50=48 nM in HT29 cell line. It is highly selective against a panel of more than 140 other kinases, such as GSK3 (Ki = 400nM), AURA (Ki = 540nM), CDK2 (Ki = 850nM), FLT3 (Ki = 1400nM), ROCK1 (Ki = 1400nM), and JNK3 (Ki = 1400nM)
Chiral purity : 100%
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