Product Name: X-396

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CAT#: A-5000


  Synonym:X-396,

X-396 Chemical Structure

X-396 chemical structure


IUPAC/Chemical name: 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]carbonyl]phenyl]-3-Pyridazinecarboxamide

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Biological Activity
X-396 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity in clinical trials. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors; ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors.
Technical Data

M.Wt:      561.44
Formula:     C26H27Cl2FN6O3
CAS#: 1370651-20-9
Purity: >99%
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.

Reference