Product Name: XL-388
 CAT#: A-1370

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 Synonym:XL-388,

XL-388 Chemical Structure
XL-388/I-BET-726 chemical structure


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Biological Activity
XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.
XL 388 is a mTOR inhibitor that inhibits in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.
Technical Data

Mol. Formula: C23H22FN3O4 S
MW: 455.50
CAS#: 1251156-08-7
Purity: >99%
Chiral Purity: 100%
XL-388 MSDS XL-388 CoA

Reference







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