Product Name:

XL-765 (SAR245409)

CAT#: A-1068    

Chemical Structure

Price of SAR-245409(XL-765)

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Biological Activity

PI3K/mTOR dual kinase inhibitor XL765
An orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR dual kinase inhibitor XL765 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Technical Data

Formula: C13H14N6O
M.Wt: 270.30
CAS No.: 934493-76-2
Solubility: DMSO
Purity: >99%
Storage Conditions :Room temperature, or -20ºC for 2 year.

XL765 Targets Tumor Growth, Survival, and Angiogenesis in Preclinical Models by Dual Inhibition of PI3K and mTOR