Price of YM-155
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YM-155 is the first-in-class survivin inhibitor, selectively inhibits survivin expression and induces apoptosis in tumor cells. YM-155 is in clinical trials. Survivin is a member of the inhibitor of apoptosis (IAP) gene family, and is expressed during embryonal development, but is absent in most normal, terminally differentiated tissues. Survivin is upregulated in a variety of human cancers. Expression of survivin in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.
1.Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs
T Iwasa, I Okamoto, K Takezawa, K Yamanaka, T Nakahara, A Kita, H Koutoku, M Sasamata, E Hatashita, Y Yamada, et al.
British Journal of Cancer 103, 36-42 (1 June 2010) doi:10.1038/sj.bjc.6605713 Full Paper