Product Name:

Z-VAD

Request
CAT#: A-4001    

Chemical Structure

Price of Z-VAD


5MG $290
10MG $390
20MG $590
We offer a substantial discount on larger orders,
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Biological Activity

Z-VAD-FMK (carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone) is a cell-permeant pan caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and can inhibit induction of apoptosis. For inhibition of apoptosis, Z-VAD-FMK should be added at the same time that apoptosis is induced. Z-VAD-FMK is provided at 20mM in DMSO for convenient addition to cell culture or extracts. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. The suggested concentration for use in the anti-Fas mAb-treated Jurkat cell culture model system is 20?M.
Technical Data

Formula:C22H30FN3O7
M.Wt: 467.49
Reference