Product Name: MLN-2480

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CAT#: A-1192


  Synonym:MLN2480; MLN-2480; MLN 2480; BIIB-024

MLN-2480 Chemical Structure MLN-2480 chemical structure


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IUPAC/Chemical name: (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

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Biological Activity

MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.

Technical Data
M.Wt:      506.30
Formula:     C17H12Cl2F3N7O2S
CAS#:     1096708-71-2
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.

Reference